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Sen räknar livet
och jag gömmer mig
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Bakom soffan 
hoppas att livet inte ska hitta mig
Men det blir varmt och trångt

Var det här du var hela tiden?
säger livet glatt.
#1 - - Ylva La:

Nobelpris 2012! I både medicin och litteratur.

#2 - - Taran:

Instämmer med Ylva La!!

#3 - - Mattias:

Wow...! /Mattias

#4 - - Zorro:

Underbart! Påminner om min favorit Werner Aspenström.

#5 - - Victoria:

Underbart vackert! Jag blir helt trollbunden!

#6 - - Maggan:

Så fint...Bästa poeten,underbart för oss att få läsa

Kram

#7 - - Anita:

Jag håller med alla andra har inget annat att skriva mer än att du skulle skriva en underbar diktbok..jag blir alldeles trollbunden av alla dina ord som sammansatta tillsammans blir så vackert...kram

#8 - - KaosJenny:

Vackert och intressant... Ska fundera på den en stund. Vi blir nog alla, mer eller mindre lekta med av livet. KRAM

#9 - - Tessa i höghuset:

Åh!

#10 - - Tina:

Du måste be din neurolog titta igenom det här.



It seems that I may have to reiterate the fact that I have solved ALS. It seems that I may also have to reiterate that it didn't happen in my dreams and is for real. Plus that it didn't occur to me by chance but was rather the consequence of a concentrated iterative process that I have been working at for about 3 years.



In layman's terms ALS (+ a lot of other ER-stress related diseases) may conceptually be regarded as a closed ulcer in the sense that it is a self-propagating cell-2-cell communicable inflammatory cellular dysfunction, which is exaggerated by the presence of activated macrophages.



The basic stage of ALS (+ a lot of other ER-stress related diseases) is standard cellular senescence. I.e. a very normal process in ageing whereby the mitochondria, for various reasons, loose their ability to produce sufficient amounts of energy, primarily in the form of NAD+ and ATP.



An energy deficit in NAD and/or ATP essentially represents cellular asphyxiation more well known as hypoxia. The well-known result of which is ER-stress and activation of the unfolded protein response (UPR). When the UPR is activated during a prolonged period, but is unable to resolve the ER-stress, the cell starts to emit inflammatory signals. These signals are interpreted as warning signals by neighboring cells that also activate their UPR to prepare and precondition themselves towards a hypoxic threat. This means that ER-stress and UPR-activation is a cell-2-cell contagious condition and it will become self-propagating if the neighboring cells also are on the brink of a cellular senescence induced energy deficit.



When a sufficient number of cells have acquired the inflammatory ER-stress/UPR-active, energy defective phenotype, the combined inflammatory signal emitted will start to attract the attention of macrophages who infiltrate the ER-stress/UPR-active and energy defective tissue and activate the innate immune response, even in the absence of an invading pathogen.



This is very bad news for the ER-stress/UPR-active and energy deficient cells, since a less well-recognized defense approach among macrophages is to employ a scorched earth tactics by gobbling up lots of nutrients, notably including NAD- and ATP-derivatives, in the perceived battle zone and use it to forge weapons like H202. This creates a localized black hole for cellular energy in the immediate vicinity of the already energy deficient and ER-stressed cells, which has been coined the NAD sink.



This means that it is essentially useless and brain dead to propose even s*it loads of different antioxidants to treat the ER-stress/UPR-active and energy deficient cells. This is of course the reason why scientists and doctors have been preaching it for so many years. It goes without saying ER-stress/UPR-active and energy deficient cells essentially are refractive to corticosteroids, but I don't think that even neurologists proposes that anymore.



However, if someone would instead ask anyone within the medical profession, or even a layman, how to treat an ulcer (but omitting the fact that it is internal and localized e.g. to the spinal cord), many would immediately respond that neither antioxidants nor anti-inflammatory corticosteroids are appropriate, but rather that some kind of oxidizing agent like hydrogen peroxide (H2O2) and a dressing allowing air (O2) to access the ulcer would be warranted for.



This is of course a bit difficult for an "internal ulcer" like ALS. But fortunately it has recently been shown (both scientifically as well as empirically) that activated chlorite whether ingested or infused can access the ER-stress/UPR-active and energy deficient cells and exert its beneficial effects (among other things probably by regenerating NAD+) in ALS.



I.e. essentially in the same fashion like i.v. WF10 has recently has been scientifically proven to do in the case of regular ulcers;



J Foot Ankle Surg. 2011 Nov;50(6):635-40. Epub 2011 Jul 1.

Effect of WF10 (immunokine) on diabetic foot ulcer therapy: a double-blind, randomized, placebo-controlled trial.

Yingsakmongkol N, Maraprygsavan P, Sukosit P.



Abstract

This randomized controlled trial was undertaken to evaluate the effect of WF10 (Immunokine) as an adjunct to the standard treatment of diabetic foot ulcer. A total of 40 participants were randomized into 2 groups of 20. One group underwent standard therapy combined with infusions of WF10, and 1 underwent standard therapy combined with placebo. The wound severity scores, which vary with the severity of infection and inflammation, necrotic and granulation tissues, and wound depth and area, were assessed weekly for 9 weeks. Before treatment, the wound severity scores were not significantly different statistically between the 2 groups (13.7 ± 2.8 and 12.9 ± 3.2). After 9 weeks, the WF10 group had a statistically significant decreased wound severity score compared with that of the placebo group (1.8 ± 1.9 versus 4.4 ± 5.3, respectively, p < .05). Subgroup analyses comparing the WF10 and placebo groups showed statistically significant decreases of infection and inflammation (0.0 ± 0.0 versus 0.8 ± 0.9, respectively, p < .01), necrotic tissue (0.0 ± 0.0 versus 0.8 ± 1.1, respectively, p < .01), and an increase of the amount of granulation tissue (0.1 ± 0.3 versus 0.8 ± 1.2, respectively, p < .05). The wound depth and wound area also decreased more in the WF10 group; however, these decreases were not statistically significant. No severe adverse events were observed throughout the observation period. We concluded that the addition of WF10 to standard wound care statistically significantly reduced the wound severity score, infection and inflammation, and necrotic tissue and enhanced the formation of granulation tissue.



PubMed



This means that the effective treatment for any ER-stress/UPR-active and energy deficient cells, notably including astrocytes and motor neurons in the spinal cord in ALS, is to deter macrophages, neutralize the NAD sink and to compensate for the energy deficit, thereby alleviating both the self-propagating inflammatory and ER-stress condition in one single blow.



Activated chlorite is a pretty good start, but since a prolonged use may deplete the stores, for example of NAD-derivatives to work with, and since the senescent mitochondria needs to be jump-started again, this thread is henceforth concerned with other and complementary approaches to the treatment of ALS. As well as all other conditions related to ER-stress/UPR-active and energy deficient cells in the bad company of activated macrophages, for that matter.

#11 - - Franck:

I ditt esse!

#12 - - Monica:

Tina! Det här är ju bara så bra!! Orden går ju bara rakt in i hjärtat. Tack för att du låter oss ta del av dom.

#13 - - judi:

Så fint och insiktsfullt du skriver om livet..

Ser att även du har fått förslag på Chlorite som behandling mot ALS Måste fråga har du funderat på att prova det ?

#14 - - Kristina S:

Tina, jag bara hoppas att det snart kommer en samling av dina dikter i bokform. Ibland är jag inte helt säker ifall det är en dikt. Kanske fanns det flera/färre dikter på din blogg än jag tror. Den här är jag i alla fall säker på och älskar från första ögonblick!

#15 - - volangen:

Ingen kan leka med orden som du.....

rakt in i mitt hjärta.

#16 - - Carina:

Underbart, Tina!

Du är en sån resurs i livet.

Skriv en bok till !

Kram

#17 - - HME:

Fin dikt! Bra att du gömmer dig dåligt..



Klorit. Spännande.. Låt oss få veta vad din neurolog säger. Man får ju också en känsla av att om det där betyder att man nu förstår signifikant mycket mer om vad som händer så ökar möjligheterna att hitta bättre mediciner rejält.



Slå tillbaka mot makrofagerna (storätarna?)!



Hilsen,

H

#18 - - O:

Vill bara säga att jag fortfarande finns här och njuter av dina senaste dikter. Funderar på dina tankar och reflektioner. Tar del. Blir ledsen, blir glad, blir berörd.

;)

#19 - - Mette:

Så vacker poesi!

#20 - - Lotta:

Tack för att du delar med dig av dina tankar. Du får mig alltid att skratta och gråta på samma gång och ger ett underbart perspektiv på det där sk. livet.